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KMID : 0378019780210010046
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New Medical Journal
1978 Volume.21 No. 1 p.46 ~ p.52
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Preliminary Survey of Glomerulonephropathies Associated with Various Diseases in Korea
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이창혜/Lee, C.H.
남양일/유수웅/박희숙/Nam, Y.I./Yoo, S.W./Park, H.S.
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Abstract
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It is well known that many of the glomerulonephropathies are triggered by immunologic mechanism. There is abundant evidence to support the role of immunologic mechanisms in the pathogenesis of human renal disease. The basic pathogenetic mechanisms include (a) Antiglomerular basement membrane glomerulonephritis and (b) Immune complex deposit glomerulonephritis. Immune complex deposit glomerulonephritis may frequently be associated with various diseases particularly mediated by immune mechanisms. For these reasons, Immunofluorescent studies of kidney biopsies have been of value in elucidating the pathogenesis of various diseases, and it is also important to evaluate the glomerulonephropathies whether or not it is associated with other diseases, because there are no excellent therapeutic methods due to lack of etiological information. In this study, a total of 47 renal biopsies done from 1974 to 1977 at National Medical Center, is conveniently classified according to the classifications of McCluskey (1974) and Kincaid-Smith (1975), and particularly analysed the glomerulonephropathies associated with other diseases. Most interesting findings are glomerulonephropathies associated with liver cirrhosis which showed Membranoproliferative glomerulonephritis in all cases. In our country, there is a report about HB Ag radioimmunoassay in patients with hepatitis, liver cirrhosis and primary hepatoma (Hann, 1977) in 93% of HBs Ag, and 100% of HBc Ag. Further immunopathological survey of the cases of hepatitis, liver cirrhosis and also primary hepatoma with glomerulonephropathies will be interesting and very important.
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KEYWORD
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